The purpose of this renewal application is to request the continuation of our Core Grant #CA 06927, for the support of the Comprehensive Cancer Center Program at Fox Chase. This grant, which was the first of its kind in the nation, was originally awarded in January 1961. The Fox Chase Center for Cancer and Medical Sciences is composed of three closely affiliated and interdigitated institutions: The Institute for Cancer Research, The American Oncologic Hospital, and Jeanes Hospital. The Center is located in Fox Chase, a district in northeast Philadelphia. The aims of this proposal are as follows: 1. Continue the supportive financial base of programs in cancer research. 2. Continue and strengthen the programs in cancer control.